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KMID : 0605820130200020053
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Korean Journal of Pediatric Infectious Diseases
2013 Volume.20 No. 2 p.53 ~ p.62
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Cross-reaction of 6B and 19F Specific Antibodies to Serotypes 6A, 6C, and 19A after Immunization with 7-valent Pneumococcal Conjugate Vaccine in Korean Children Aged 12-23 Months
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Kim Kyung-Hyo
Yang Joo-Yun
Park In-Ho
Lim Soo-Young
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Abstract
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Purpose: The cross-protection of 7-valent pneumococcal conjugate vaccine (PCV7) against vaccine-related serotypes has
been controversial. We investigated the serological properties of cross-protective antibodies against vaccine-related
serotypes 6A, 6C, and 19A induced in young children aged 12-23 months after booster immunization of PCV7.
Methods: IgG and IgM antibody concentrations and opsonic index (OI) against vaccine serotypes 6B and 19F and vaccinerelated
serotypes 6A, 6C, and 19A were measured by ELISA and opsonophagocytic killing assay (OPA) in 4 selected immunesera.
The serological properties and antigenic specificity of protective antibodies were determined by IgM depletion
of immunesera, OPA, and competitive OPA against serogroup 6 and 19 pneumococci.
Results: Compared to pre-IgM depleted immunesera, OI of IgM-depleted immunesera against 6B and 19F decreased and
OI against 6A, 6C, and 19A decreased, too. In competition OPA, free 6B and 19F polysaccharide completely inhibited the
immune protection against vaccine-related serotypes 6A, 6C, and 19A as well as vaccine types 6B and 19F.
Conclusions: The booster immunization of PCV7 certainly induced cross-protective antibodies against vaccine-related
serotypes 6A, 6C, and 19A with both IgG and IgM isotypes. Furthermore, IgM antibodies are more highly contributed to
opsonophagocytic activity against vaccine-related serotypes as well as most of vaccine types than do IgG antibodies.
Further studies are needed for the more immunized sera in the children as well as adults.
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KEYWORD
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Streptococcus pneumoniae, Heptavalent pneumococcal conjugate vaccine, Antibodies, Immunoglobulin M, Cross protection
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